Unlocking DNA to Find A Cure For Trigeminal Neuralgia
Dr. Marshal Devor Dr. Kim Burchiel Dr. Ze'ev Seltzer
Imagine unlocking the mysteries of DNA that are so extraordinary and then
applying those learning’s to finding a cure for the worst pain known to humankind.
Our DNA functions as the building blocks, or blue prints of life. We all carry these
building blocks within every cell of our body.
For many years patients have asked themselves and their doctors “why me?
Why did I get this awful painful condition called trigeminal neuralgia?...Why do I
suffer so and others don’t understand...why do I feel like I could simply die?”
The Facial Pain Research Foundation’s first international research project to find
a cure is underway and it seeks to discover the answers to “Why Me?” and lead
scientists to developing a cure.
The Foundation’s Trustees are excited to announce their fourth research project
entitled “In Search of A Cure...Finding The Genes That Predispose to Trigeminal
Neuralgia”. It’s goal is to identify the genes that make people susceptible to TN
or cause the pain and then move toward prevention and cure.
Dr. Douglas Anderson, Foundation Trustee and Director of Research Programs,
first presented the concept that there was likely a genetic basis for TN at the 2004
TNA National Conference in Orlando. He always found it odd that the anatomy of
compressed nerves/lesions were seen in a significant number of individuals but
only a few had TN. He always harbored the idea of identifying a genetic profile in
TN patients that would lead to ending the painful condition. Anderson says “If there
is a history of a member of your family having TN, other members of your family
could be screened and hopefully the condition could be prevented by having
the genetic pattern altered so the pain will not develop.”
Dr. Joanna Zakrzewska of London England, the Foundation’s International
Research Coordinator, asked Dr. Marshall Devor in March 2012 to prepare a
research project proposal to seek a cure for TN and present it to the Foundation.
After seven months, the researchers and the Foundation Trustees have approved
the research project and are excited about moving forward. The three Principal
Investigators of the project are Dr. Marshall Devor, Dr. Kim Burchiel and Dr. Ze’ve
The team of international scientists is led by Principal Investigator pain research
pioneer Dr. Marshall Devor of the Hebrew University of Jerusalem, Israel.
The award winning scientist has had an outstanding career in pain research.
He has contributed an outstanding body of research, authoring several hundred
papers over 40 years and has been been described as one of those “who view
excellence as a way of life and the fulfillment of human potential as essential
to creating a better world for future generations.”
Dr. Kim Burchiel is the Chairman of the Department of Neurological Surgery
at the Oregon Health & Science University in Portland, Oregon. Burchiel has
been a long time member of the TNA Medical Advisory Committee and performed
hundreds of TN surgeries. A successful researcher, he has been a national
leader in the treatment of orofacial pains including TN. The first step of the
research project, phenotyping and DNA collection, will be the responsibility of
Professor Burchiel at OHSU. He is a leading authority in the phenotyping of
facial pain conditions and author of the most widely accepted TN classification
scheme. Dr. Burchiel has said: “this research project could be the most important
pain study ever attempted” and he is very hopeful that it will lead to a cure for
TN and related neuropathic pain.
Dr. Ze’ev Seltzer, Professor of Genetics at The University of Toronto, Canada
is also an award winning scientist. He has dedicated his career to the study of pain.
Seltzer says “ I am looking forward to be a Co-Principal Investigator in the
TN project, bringing 35 years of studying the neurobiology of pain.” Having
had many competitive grants and honors he has an outstanding track record of
productivity in the field of pain and pain genetics. Seltzer also says
“The goal to find a cure is achievable...our best salvation may come from genetics”.
Consultants to the research project include: Dr. Joanna Zakrzewska, Eastman
Dental Hospital, London, England...Professor Ariel Darvasi and Dr. Sagiv Shifman,
Hebrew University of Jerusalem, Israel...and Dr. Scott Diehl, University of Medicine
and Dentistry, New Jersey.
If you have any questions or comments please
address them to the Foundation at:
Success in answering critical questions about the role of genes in TN and other
nerve-related facial pains relies on private support. Here are ways in which donors
at all levels can join The Facial Pain Research Foundation in finding a solution:
- Support full expenses of one patient in the study: $1,770
- Pay for the genotyping of one research participant: 1,100
- Help with the phenotyping costs for one participant: 600
- DNA extraction from one person’s saliva samples 40
- Pay for saliva kit & shipping cost for one participant 30