External TN Research Projects
| Institution | Molecule | Type of Product | Discovery | Developoment | Preclinical | Phase 1 | Phase 2 | Phase 3 | Status |
|---|---|---|---|---|---|---|---|---|---|
| University of Pittsburg | Determine role of NaV and GABBA subunits in TN | X | |||||||
| Atalanta | ATL 301 modulator of SCN9A gene (Nav 1.7) | siRNA, small interfering RNA that can interfere with the expression level of targeted genes. | X | Has two drugs for epilepsy and Huntington in preclinical phase nearing clinical trials | |||||
| Initiator Pharm | IPTN2021 | Unique inhibitor of monoamine transporters of Dopamine, Serotonin and Noradrenaline. | X | In Ph1 study with healthy subjects efficacy was 2 times better than pregabalin. Planning Ph2 study with TN patients. | |||||
| Hoba | HB-086 | Recombinant human meteorin. Promotes Neurites growth, protects nerve cells from damage and regulates myelination in the nervous system. | X | Finalizing preclinical studies | |||||
| Octavian Therapeutics | OCT130401 | Inhaler dosed Phyto cannabinoids THC/CBD | X | Ready to move into TN Ph1 trial subject to funding | |||||
| Kriya | Kriya 748 | AAV injection into TN nerve expressing modified gated ion channel, controlled by oral Varenicline that reduces neuron excitability | X | Therapy from RedpinRx via HHM | |||||
| Undaunted Bio | UDB412 | Repurposed drug being reformulated into oral thin film that releases drug quickly | X | Aiming towards a 505b clinical trial in 2026 | |||||
| Noema | Basimglurant | Allosteric modulator of mGLUR5 | X | Recruiting for Ph2/3 clinical trial |